Ethanol → 5-Methyl-5-(4-pyridyl)hydantoin

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-acetyl pyridine (3.0 mL), NH4HCO3 (7.73 g), KCN (2.16 g), and concentrated NH4OH (8.2 mL) in EtOH (10.35 mL) was heated to 60° C. overnight under a reflux condenser. The reaction mixture was extracted with ether, then acidified to pH 4.5 with concentrated HCl and extracted with EtOAc. The combined organic extracts from the acidic extraction were dried over Na2SO4. Solvent was removed in vacuo to yield crude 5-methyl-5-(4-pyridyl)-imidazolidinedione as an off-white solid.

Provenance & Evidence