HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydantoin → 1-[(4-Methoxyphenyl)methyl]imidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydantoin | HCID 10006 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 1-[(4-Methoxyphenyl)methyl]imidazolidine-2,4-dione | HCID 21911028 | — |
Reaction Steps
A mixture of imidazolidine-2,4-dione (5.01 g), Cs2CO3, and 4-methoxybenzyl chloride (8.0 mL) in DMF (250 mL) was allowed to react overnight. The reaction was added to 400 mL brine then extracted with ether. The desired product precipitated from the ether, and was collected by filtration to yield 1-(4-methoxybenzyl)-imidazolidine-2,4-dione as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07125865B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ba3e2795c759446fa485ec76e48a605a |
| Source note | uspto-grants-2006_10 |