HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 21911046, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Trifluoromethyl-7-propyl-6-(3-bromopropyloxy)-benzisoxazole | HCID 12031259 | — |
| Reactant | 1-[(4-Methoxyphenyl)methyl]imidazolidine-2,4-dione | HCID 21911028 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21911046 | HCID 21911046 | — |
Reaction Steps
A mixture of 1-(4-methoxybenzyl)-imidazolidine-2,4-dione (57 mg), 7-propyl-3-trifluoromethyl-6-(3-bromopropyloxy)-1,2-benzisoxazole from Example 7 (86 mg), and Cs2CO3 (146 mg) in DMF (4.0 mL) was allowed to react overnight. Water was added and the mixture separated by HPLC to yield 1-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)-3-(4-methoxybenzyl)-imidazolidine-2,4-dione as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07125865B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-0e384d3d6d3b4495bbdb6cde7de34a03 |
| Source note | uspto-grants-2006_10 |