反应详情

A mixture of 4-[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]butyl methanesulfonate (60 mg, 0.16 mmol), from this Example step 5, Cs2CO3 (206 mg, 0.63 mmol) and 5,6-dihydrouracil (54.2 mg, 0.48 mmol) in dry DMF (1.5 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. Combined organic extracts were washed with water and brine, dried over Na2SO4 and the solvent evaporated in vacuo. The residue was purified by preparative TLC using ethyl acetate to give the title compound.

1. customwas stirred at room temperature overnight
2. customThe reaction mixture was partitioned between ethyl acetate and water
3. washCombined organic extracts were washed with water and brine
4. dry with materialdried over Na2SO4
5. customthe solvent evaporated in vacuo
6. customThe residue was purified by preparative TLC