Morpholine-3,5-dione → 4-(3-{[7-Propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)morpholine-3,5-dione

HRID 1245349Notes

Reaction equation

HRID 1245349 reaction equation
[NH:1]1[C:6](=[O:7])[CH2:5][O:4][CH2:3][C:2]1=[O:8].[CH2:9]([C:12]1[C:20]2[O:19][N:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[C:16]=2[CH:15]=[CH:14][C:13]=1[O:25][CH2:26][CH2:27][CH2:28]Br)[CH2:10][CH3:11]>>[CH2:9]([C:12]1[C:20]2[O:19][N:18]=[C:17]([C:21]([F:22])([F:24])[F:23])[C:16]=2[CH:15]=[CH:14][C:13]=1[O:25][CH2:26][CH2:27][CH2:28][N:1]1[C:6](=[O:7])[CH2:5][O:4][CH2:3][C:2]1=[O:8])[CH2:10][CH3:11]

Participants

3

Reactant 2

HCID 364836Morpholine-3,5-dioneHCID 12031259HCID 12031259, compound

Product 1

HCID 219110044-(3-{[7-Propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)morpholine-3,5-dione

Procedure

4-(3-{[7-Propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)morpholine-3,5-dione was prepared as for Example 10 from morpholine-3,5-dione and the bromide from Example 7. After aqueous work-up and silica gel chromatography, the title compound was obtained.

Sources & evidence

ORD record
ord-64fd8cf315c148f9b2a54ae7a1b6dcf3
Source dataset
uspto-grants-2006_10
Patent number
US07125865B2

Reaction notes

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