Piperazin-2-one → HCID 21911035, compound

HRID 1245350Notes

Reaction equation

HRID 1245350 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][C:2]1=[O:7].[CH2:8]([C:11]1[C:19]2[O:18][N:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[C:15]=2[CH:14]=[CH:13][C:12]=1[O:24][CH2:25][CH2:26][CH2:27]Br)[CH2:9][CH3:10]>>[CH2:8]([C:11]1[C:19]2[O:18][N:17]=[C:16]([C:20]([F:21])([F:23])[F:22])[C:15]=2[CH:14]=[CH:13][C:12]=1[O:24][CH2:25][CH2:26][CH2:27][N:4]1[CH2:5][CH2:6][NH:1][C:2](=[O:7])[CH2:3]1)[CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 12031259HCID 12031259, compound

Product 1

HCID 21911035HCID 21911035, compound

Procedure

4-(3-{[7-Propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)piperazine-2-one was prepared as for Example 10 from piperazine-2-one and the bromide from Example 7. After aqueous work-up and silica gel chromatography, the title compound was obtained.

Sources & evidence

ORD record
ord-d6d0dbfec1b64f2c9602a589b76a3dfa
Source dataset
uspto-grants-2006_10
Patent number
US07125865B2

Reaction notes

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