(2S)-2,5-Dihydro-2-isopropyl-3,6-dimethoxypyrazine → (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-isopropyl-5-(4'-bromo-2,5'-difluorobenzyl)pyrazine

참여 물질

반응 단계

The title compound (1.61 g) was prepared from 0.865 g (4.7 mmol) of (2S)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine and 1.5 g (5.2 mmol) of 4-bromo-2,5-difluorobenzyl bromide using the procedure described for Intermediate 2, Step A. 1H NMR (400 MHz, CDCl3) δ 7.21 (m, 1H), 6.97 (m, 1H), 4.25 (m, 1H), 3.78 (s, 3H), 3.70–3.64 (m, 4H), 3.25–3.18 (m, 1H), 2.96–2.90 (m, 1H), 2.25–2.16 (m, 1H), 1.01 (d, 3H, J=8 Hz), 0.65 (d, 3H, J=8 Hz).

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