Hydrochloric Acid → HCID 131725993, compound

Participants

Reaction Steps

The title compound was prepared from 7-[(3R)-3-[(1,1-dimethylethoxycarbonyl)-amino]-4-(2,5-difluorophenyl)butanoyl]-5,6,7,8-tetrahydroimidazo[1,2-α]pyrazine (349.8 mg, 0.72 mol, from Step A) in 1.5 mL of methanol saturated with hydrogen chloride, using a procedure analogous to that described in Example 1, Step D. Evaporation of solvent gave 299 mg of the title compound as a foamy solid. 1H NMR (500 MHz, CD3OD): δ 3.10–3.17 (m, 2H), 2.89–2.99 (m, 2H), 3.94–4.22 (m, 4H), 4.33 (m, 1H), 4.91–5.48 (m, 2H), 7.07–7.23 (m, 3H), 8.05 (m, 1H). ESI-MS 389(M+1).

Provenance & Evidence