Imidazo(1,2-a)pyrazine → 5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine

HRID 1245374Notes

Reaction equation

HRID 1245374 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12>CO.[Pt]=O>[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12

Participants

4

Reactant 1

HCID 2771670Imidazo(1,2-a)pyrazine

Product 1

HCID 132470465,6,7,8-Tetrahydroimidazo(1,2-a)pyrazineYield 99%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

The title compound was prepared from imidazo[1,2-α]pyrazine (500 mg, 4.20 mmol, from Step A) and platinum oxide (250 mg) in methanol (50 mL), using a procedure analogous to that described in Example 1, Step B. Concentration gave the title compound (512 mg) as a viscous oil. 1H NMR (500 MHz, CD3OD) δ 3.37 (t, 1H, J=5.5 Hz), 4.18 (t, 2H, J=5.6 Hz), 4.88 (s, 1H), 7.27 (d, J=1.6 Hz, 1H), 7.33 (d, 1H).

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-e2e2e6925f064fe8be81c9a48bab0b46
Source dataset
uspto-grants-2006_10
Patent number
US07125873B2

Reaction notes

Loading…