8-Chloro-3-ethyl-[1,2,4]triazolo[4,3-A]pyrazine → 3-Ethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

HRID 1245376Notes

Reaction equation

HRID 1245376 reaction equation
[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH2:11][CH3:12])=[N:9][N:10]=2)[CH:5]=[CH:6][N:7]=1>CO.[Pt]=O>[ClH:1].[CH2:11]([C:8]1[N:4]2[CH2:5][CH2:6][NH:7][CH2:2][C:3]2=[N:10][N:9]=1)[CH3:12]

Participants

4

Reactant 1

HCID 299234618-Chloro-3-ethyl-[1,2,4]triazolo[4,3-A]pyrazine

Product 1

HCID 670584843-Ethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

The title compound was prepared from 8-chloro-3-ethyl-1,2,4-triazolo[4,3-α]pyrazine (2.70 g, 14.8 mmol, from Step A) and platinum oxide (0.4 g) in 200 mL of methanol in a paar shaker under hydrogen (50 psi) for 14 hours. Filtration through Celite followed by concentration gave the title compound as a solid.

Workup

  1. filtrationFiltration through Celite
  2. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-240b33ea44a44b4a9e30c0f4f1605bdb
Source dataset
uspto-grants-2006_10
Patent number
US07125873B2

Reaction notes

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