反应详情

Following a procedure analogous to that used in Example step 1c, but using 2-methyl-but-3-enoic acid methyl ester and 4-(2-methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime from step 1b, the crude product was prepared. The crude product was purified by FCC (flash column chromatography) on silica gel to give 2-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester (0.13 g, 55%) as a solid residue. MS found: (M+H)+=405.

1. customthe crude product was prepared
2. customThe crude product was purified by FCC (flash column chromatography) on silica gel