反应详情

Following a procedure analogous to that used in Example step 1c, but using the product from step 8b and 4-(2-methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime from step 1b, the crude product was prepared and purified by FCC on silica gel eluting ethyl acetate:hexanes (gradient) to give 2-tert-butoxycarbonylamino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester (1.15 g, 65%) as an oil. MS found: (M+H)+=520.

1. customthe crude product was prepared
2. custompurified by FCC on silica gel
3. washeluting ethyl acetate