反应详情

Trifluoroacetic acid (1 mL) was added to a solution of 2-tert-butoxycarbonylamino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester from Example step 8c in methylene chloride at room temperature. After stirring for 1 h, the reaction was concentrated in vacuo to give 2-amino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester trifluoroacetate salt (0.1 g, 100%) as an oil. MS found: (M+H)+=420.

1. concentrationthe reaction was concentrated in vacuo