Trifluoroacetic acid → 2-Amino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester trifluoroacetate salt

HRID 1245391노트

반응식

HRID 1245391 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][O:9][C:10](=[O:45])[CH:11]([NH:37]C(OC(C)(C)C)=O)[CH2:12][CH:13]1[O:17][N:16]=[C:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[N:29]=[C:28]([CH3:36])[CH:27]=3)=[CH:20][CH:19]=2)[CH2:14]1>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][O:9][C:10](=[O:45])[CH:11]([NH2:37])[CH2:12][CH:13]1[O:17][N:16]=[C:15]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:25][C:26]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[N:29]=[C:28]([CH3:36])[CH:27]=3)=[CH:22][CH:23]=2)[CH2:14]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 696398152-Tert-butoxycarbonylamino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester

생성물 1

HCID 696399912-Amino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester trifluoroacetate salt수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (1 mL) was added to a solution of 2-tert-butoxycarbonylamino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester from Example step 8c in methylene chloride at room temperature. After stirring for 1 h, the reaction was concentrated in vacuo to give 2-amino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester trifluoroacetate salt (0.1 g, 100%) as an oil. MS found: (M+H)+=420.

후처리

  1. concentrationthe reaction was concentrated in vacuo

출처 및 근거

ORD 기록
ord-5ad3e13c2e534bd296a9ad76926d156b
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125870B2

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