反应详情

温度

60 °C

The product from step 10c (0.3 g, 0.67 mmol) was dissolved in methanol (10 mL) and condensed ammonia (10 mL) in a stainless steel pressure reactor and heated to 60° C. for 5 h. The reaction was complete and was concentrated to give 3-amino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid tert-butyl ester (0.3 g, 97%) as an oil. MS found: (M+H)+=462.

1. concentrationwas concentrated