HCID 69639797, compound → HCID 136336352, compound

Participants

Reaction Steps

2-{3-[4-(2-Methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-cyclopent-1-enecarboxylic acid methyl ester intermediate from Example 27, was dissolved in ethyl acetate:methanol (1:1) (20 mL), degassed with nitrogen, and charged with 10% palladium on carbon and 50 PSI hydrogen. The reaction was shaken for 3 h, filtered, and concentrated to give cis-2-[3-(4-hydroxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-cyclopentanecarboxylic acid methyl ester (0.127 g, 100%) as an oil. MS found: (M+H)+=290.

Provenance & Evidence