Trifluoroacetic acid → HCID 69639776, compound

Participants

Reaction Steps

The intermediate 6-methoxycarbonylmethyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-1-oxa-2,8-diaza-spiro[4.5]dec-2-ene-8-carboxylic acid tert-butyl ester from Example 33 (0.43 g, 1.87 mmol) was dissolved in methylene chloride (12 mL) and TFA (12 mL) at room temperature under a nitrogen atmosphere. The reaction was stirred for 1 h and concentrated in vacuo to give {3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-1-oxa-2,8-diaza-spiro[4.5]dec-2-en-6-yl}-acetic acid methyl ester (1.2 g, 100%) crude product. MS found: (M+H)+=460.

Provenance & Evidence