Trifluoroacetic acid → HCID 69640163, compound

Participants

Reaction Steps

The intermediate 3-ethoxycarbonylmethyl-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester (0.35 g, 0.61 mmol) from example 41 was dissolved in methylene chloride (5 mL) and TFA (3 mL) under nitrogen atmosphere at room temperature. The reaction was stirred for 2 h and was concentrated in vacuo to give (3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-pyrrolidin-3-yl)-acetic acid ethyl ester as a crude oily residue. MS found: (M+H)+=474.

Provenance & Evidence