Sodium Cyanide → HCID 21912474, compound

HRID 1245416Notes

Reaction equation

HRID 1245416 reaction equation
[C-:1]#[N:2].[Na+].[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[CH:17]=[C:16]([F:18])[N:15]=[C:14](F)[N:13]=2)=[CH:7][CH:6]=1>CS(C)=O>[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[CH:17]=[C:16]([F:18])[N:15]=[C:14]([C:1]#[N:2])[N:13]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 21912477HCID 21912477, compound

Product 1

HCID 21912474HCID 21912474, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Sodium cyanide (0.046 g) was added to a solution of the product from step (i) (0.113 g) in dimethylsulphoxide (3 ml) and stirred at room temperature for 1.5 h. The mixture was partitioned between ethyl acetate and water, the organics washed with water, dried (MgSO4), and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/ethyl acetate (4:1). Yield 0.036 g

Workup

  1. customThe mixture was partitioned between ethyl acetate and water
  2. washthe organics washed with water
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure
  5. customThe residue was purified by chromatography on silica eluting with isohexane/ethyl acetate (4:1)

Sources & evidence

ORD record
ord-7d5c31d9442240a38f25aba98e35f7f5
Source dataset
uspto-grants-2006_10
Patent number
US07125881B2

Reaction notes

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