反应详情

Sodium cyanide (0.057 g) was added to a solution of the product from step (ii) (0.2 g) in dimethylsulphoxide (5 ml) and the mixture stirred at room temperature. After 18 h, the mixture was partitioned between ethyl acetate and water, the organics separated, washed with water, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5% ethyl acetate in toluene. Yield 0.09 g

1. customthe mixture was partitioned between ethyl acetate and water
2. washthe organics separated, washed with water
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customThe residue was purified by chromatography on silica eluting with 5% ethyl acetate in toluene