4-Chloroaniline → HCID 21912462, compound

Participants

Reaction Steps

A solution of the product from step (iii) (4 g) and 4-chloroaniline (5.3 g) in ethanol (40 ml) was heated under reflux for 16 h then the solvent removed under reduced pressure. The residue was partitioned between ethyl acetate and 2M hydrochloric acid, the organics washed with water, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 10–15% ethyl acetate in isohexane. Yield 4.99 g

Provenance & Evidence