HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate → N-(Piperidin-4-yl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate | HCID 11357119 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | N-(Piperidin-4-yl)pyridin-2-amine | HCID 21912674 | 166.4% |
Reaction Steps
6 g of ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate (23a) were refluxed in 30 ml of 47% HBr for 6 h. Evaporation of the mixture, trituration of the resulting crude product with ethyl acetate/CH3OH (9:1) and renewed drying afforded 7.1 g of white solid; ESI-MS [M+H+]=178.15.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07125883B1 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-a7ad09585266425da852695aa3693fbe |
| Source note | uspto-grants-2006_10 |