Trifluoroacetic acid → HCID 86760281, compound

Participants

Reaction Steps

tert-Butyl 4-{[(2-aminoanilino)carbothioyl]amino}benzylcarbamate (4.3 g; 11.54 mmol) was refluxed in analogy to 21c with 5 g of HgO (yellow) and 0.05 g of sulfur in 150 ml of ethanol. Filtration of the reaction mixture through Celite and concentration afforded 2.1 g of a dark solid (ESI-MS [M+H+]=339.15). The tert-butyl 4-(1H-benzimidazol-2-ylamino)benzylcarbamate obtained in this way was treated without further purification with 15 ml of TFA at RT for 2 h, and concentration afforded 4.7 g of a dark oil which was reacted further without further purification (ESI-MS [M+H+]=239.05).

Provenance & Evidence