反应详情

温度

23 °C

A mixture of 4-(3-phenylimidazo[1,2-a]pyridin-7-yl)benzaldehyde (2-5, 75 mg, 0.25 mmol, 1 equiv), 4-(methylsulfonyl)piperazine (49 mg, 0.30 mmol, 1.2 equiv), sodium triacetoxyborohydride (64 mg, 0.30 mmol, 1.2 equiv), acetic acid (14 μL, 0.25 mmol, 1.0 equiv), and 4-angstrom molecular sieves (50 mg) in 1,2-dichloroethane (5 mL) was stirred at 23° C. for 18h. The reaction mixture was filtered, and the filtrate concentrated. The residue was purified by reverse-phase liquid chromotography (H2O/CH3CN gradient w/0.1% TFA) to provide [4-(3-phenylimidazo[1,2-a]pyridin-7-yl)phenyl]methanol (2-6) and 7-(4-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-phenylimidazo[1,2-a]pyridine (2-7).

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate concentrated
3. customThe residue was purified by reverse-phase liquid chromotography (H2O/CH3CN gradient w/0.1% TFA)