Ammonium Hydroxide → [4,4'-Bipyridin]-2-amine

HRID 1245482노트

반응식

Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.[OH-].[NH4+:15]>>[NH2:15][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 135337182-Chloro-4,4'-bipyridine

생성물 1

HCID 21912841[4,4'-Bipyridin]-2-amine

반응 조건

온도: 180 °C

실험 절차

The mixture of 2-chloro-4,4′-bipyridine (2.40 g, 12.59 mmol) and concentrated ammonium hydroxide (100 mL) in a steel bomb was heated to 180° C. for 36 h. The volatiles were then removed in vacuo to give 2-amino-4,4′-bipyridine as a solid. 1H NMR (CDCl3) δ 8.71 (m, 2H), 8.18 (d, 1H, J=5.3), 7.48 (m, 2H), 6.8 (m, 1H), 6.72 (s, 1H). LRMS m/z (M+H) Calcd: 172.2, found: 172.2.

후처리

customThe volatiles were then removed in vacuo

출처 및 근거

ORD 기록: ord-9fa85c118d71468f851aa3aa73809b8e
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07125888B2

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