Ammonia → (2R,3R,4R,5R)-2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol

Participants

Reaction Steps

A mixture of the product from Step B of Example 118 (24 mg) in aqueous ammonia (30%, 10 mL) was heated in a stainless steel autoclave at 100° C. overnight, then cooled and evaporated. The residue was purified on a silica gel column with CH2Cl2/MeOH (10/1 and 5/1) as the eluent to afford the title compound (15 mg).

Provenance & Evidence