Sodium Hydroxide → HCID 23720218, compound

HRID 1245557Notes

Reaction equation

HRID 1245557 reaction equation
C[O:2][C:3](=[O:23])[CH2:4][NH:5][NH:6][C:7]([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[CH2:11][CH2:10]1)=[O:8].[OH-].[Na+:25]>O1CCOCC1.CO>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][N:12]2[CH2:13][CH2:14][N:9]([C:7]([NH:6][NH:5][CH2:4][C:3]([O-:23])=[O:2])=[O:8])[CH2:10][CH2:11]2)=[CH:21][CH:20]=1.[Na+:25]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54147978HCID 54147978, compound

Product 1

HCID 23720218HCID 23720218, compound

Reagents, catalysts & solvents 1

HCID 21966525Dioxane MethanolSolvent

Procedure

A solution of N-(1-(4-chlorobenzyl)-piperazine-4-carboxamido) glycine methyl ester (813 mg, 2.50 mmol) in dioxane-CH3OH (3:1, 12 mL) was treated with 4N aqueous NaOH solution (0.63 mL, 1 equiv.). The mixture was stirred at room temperature for 2 hours. Solvent removal afforded the desired material which was used without further purification (885 mg, 100%).

Workup

  1. customSolvent removal

Sources & evidence

ORD record
ord-5ff4848c368144b6ba11871515a82c32
Source dataset
uspto-grants-2006_10
Patent number
US07125895B1

Reaction notes

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