Aniline → HCID 21914244, compound

Participants

Reaction Steps

Sodium N-(1-(4-chlorobenzyl)-piperazine-4-carboxamido)glycinate (20 mg, 0.060 mmol) and aniline (6.2 mg, 0.66 mmol) were dissolved in CHCl3 (1 mL). HBTU (25 mg, 0.066), HOBt (8.1 mg, 0.066 mmol) and Et3N (17 μL, 0.12 mmol) were added and the reaction mixture was stirred for 16 hr. The solvent was removed and the compound was dissolved into CH2Cl2 (2 mL). The organic layer was washed with 2N aqueous NaOH solution (2N mL), brine (1×1 mL) and concentrated. Purification via RPLC/MS afforded the desired material (6.4 mg, 21%). ESI/MS 385 (M++H, C26H24ClN3O2).

Provenance & Evidence