Dibenzyl ethylmalonate → 2-Formyl-butyric acid, benzyl ester

Participants

Reaction Steps

The title compound was prepared from ethylmalonic acid, dibenzyl ester (from Step A) using a procedure analogous to that described for Aldehyde 3, Step B. RF: 0.35 (9:1 v/v hexane/EtOAc); 1H-NMR (500 MHz: Equilibrium mixture of aldehyde and enol) δ 0.92–1.00 (m), 1.04–1.08 (m), 1.93–2.01 (m), 2.14–2.18 (m), 5.17, 5.23, 5.26 (3s), 7.05 (d, J=12.6), 7.30–7.41 (m), 9.74 (d, J=2.3), 11.33 (d, J=12.6).

Provenance & Evidence