Trifluoroacetic acid → HCID 21912779, compound

Participants

Reaction Steps

A solution of 500 mg (1.3 mmol) of 1-tert-butoxycarbonyl-4-(2-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-(2H)-indazol-3-yl)piperidine (from Step B) in 4.1 mL of CH2Cl2 at 0° C. was treated with 2.7 mL of trifluoroacetic acid. After 30 min volatiles were removed under reduced pressure. The residue was partitioned between 25 mL of CH2Cl2 and 25 mL of 1 N NaOH. After separating phases, the aqueous layer was extracted with 25 mL of 1 N NaOH. The combined organic layers were dried over Na2SO4 and concentrated to afford the title compound, which was used without further purification. 1H-NMR (500 MHz) δ 1.68–1.95 (m, 9H), 2.61–2.71 (m, 7H), 3.17–3.20 (m, 2H), 4.61 (q, J=8.3, 2H).

Provenance & Evidence