Hydrazine → HCID 21912759, compound

Participants

Reaction Steps

A solution of 595 mg (1.9 mmol) of ethyl 2-(R/S)-(1-tert-butoxycarbonyl-piperidin-4-yl)-3-oxo-butanoate (from Step B) and 0.06 mL (1.9 mmol) of hydrazine in 10 mL of xylenes was heated at reflux for 2 h. The resulting mixture was cooled to rt and the solid that precipitated was filtered and dried to afford the title compound. 1H-NMR (500 MHz, CD3OD) δ 1.45 (s, 9H), 1.60 (app d, J=12.0, 2H), 1.83 (dq, J=4.0, 13.0, 2H), 2.14 (s, 3H), 2.52–2.58 (m, 1H), 2.65–2.85 (br s, 2H), 4.13 (d, J=13.5, 2H), 4.81 (s, 2H).

Provenance & Evidence