Dimethyl Carbonate → HCID 69666080, compound

HRID 1245609Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2NN[C:16](=[O:19])[C:15]=2[CH3:20])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:21]([O:28][CH2:29]C(OC)=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C[O:35]C(=O)OC>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[O:35])[CH:15]([CH3:20])[C:16](=[O:19])[CH2:29][O:28][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 3

HCID 12021Dimethyl Carbonate

HCID 11745225Methyl 2-(benzyloxy)acetate

HCID 21912822HCID 21912822, compound

Product 1

HCID 69666080HCID 69666080, compound

Procedure

The title compound was prepared using a procedure analogous to that described for Piperidine 15, Step B, except benzyloxyacetic acid, methyl ester was substutited for dimethylcarbonate. RF: 0.27 (4:1 v/v hexanes/acetone); 1H-NMR (500 MHz) δ 1.27 (d, J=6.9, 3H), 1.43–1.86 (m, 15H), 2.54–2.70 (m, 3H), 3.78–4.76 (m, 5H), 7.27–7.40 (m, 5H).

Sources & evidence

ORD record: ord-afb43f4865854f2db693384e29d7cf17
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07125887B2

Reaction notes

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