tert-Butyl 4-(1-bromo-2-oxoethyl)piperidine-1-carboxylate → HCID 21912742, compound

Participants

Reaction Steps

The title compound was prepared from 1-(tert-butoxycarbonyl)-4-(1-ethyl-3-benzyloxymethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (from Step B) using a procedure analogous to that described for Pyrrolidine 1, Step E. RF: 0.21 (3:2 v/v hexanes/acetone); 1H-NMR (500 MHz) δ 1.36 (t, J=7.2, 3H), 1.48 (s, 9H), 1.67–1.70 (m, 2H), 1.84–1.93 (m, 2H), 2.08 (s, 3H), 2.74–2.80 (m, 3H), 3.14 (br m, 1H), 4.10 (q, J=7.2, 2H), 4.12–4.26 (m, 2H), 4.59 (s, 2H).

Provenance & Evidence