Piperidine → HCID 23557502, compound

Participants

Reaction Steps

The title compound was prepared from (2R/S, 3R/S)-2-(1-tert-butoxycarbonyl-piperidin-4-yl)-7-chloro-3-hydroxy-heptanoic acid, ethyl ester (from Step A) using a procedure analogous to that described for Piperidine 8, Step D. RF: 0.30 (4:1 v/v hexanes/EtOAc); 1H-NMR (500 MHz) δ 1.09–1.22 (m, 2H), 1.27 (t, J=7.1, 3H), 1.45 (s, 9H), 1.55 (m, 1H), 1.63–1.79 (m, 5H), 2.29 (m, 1H), 2.46–2.75 (m, 4H), 3.30 (d, J=9.6, 1H), 3.51–3.54 (m, 2H), 4.06–4.21 (m, 4H).

Provenance & Evidence