HCID 86760286, compound → HCID 86760287, compound

Participants

Reaction Steps

The title compound was prepared from 1-{[(3R,4S)-3-formyl-4-(3-fluorophenyl)pyrrolidin-1-yl]methyl}cyclohexanecarboxylic acid, benzyl ester (from Step C) and 4-(2-ethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)-piperidine, hydrochloride salt (Prepared as Piperidine 9 above) using a procedure analogous to that described in Example 1, Step D. 1H NMR (500 MHz, CDCl3) δ 1.22 (t, 3H, J=7.6 Hz), 1.23–1.50 (m, 6H), 1.50–1.70 (br m, 5H), 1.70–2.00 (m, 8H), 2.17 (br d, 2H, J=12.3 Hz), 2.20–2.40 (m, 5H), 2.57 (q, 2H, J=7.3), 2.61–2.96 (m, 9H), 4.07 (t, 2H, J=6.0 Hz), 5.16 (m, 2H), 6.85 (dt, 1H, J=1.8, 8.5 Hz), 7.02–7.10 (m, 2H), 7.20 (q, 1H, J=6.5 Hz), 7.25–7.40 (m, 5H).

Provenance & Evidence