2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-dichloro-6-methyl-N-(4-pentyl-1,3-thiazol-2-yl)benzenesulfonamide

HRID 1245643Notes

Reaction equation

HRID 1245643 reaction equation
[CH2:1]([C:6]1[N:7]=[C:8]([NH2:11])[S:9][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[Cl:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([CH3:20])[C:14]=1[S:21](Cl)(=[O:23])=[O:22]>>[Cl:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([CH3:20])[C:14]=1[S:21]([NH:11][C:8]1[S:9][CH:10]=[C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[N:7]=1)(=[O:23])=[O:22]

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 133294812-Amino-4-pentylthiazole

Product 1

HCID 101786572,4-dichloro-6-methyl-N-(4-pentyl-1,3-thiazol-2-yl)benzenesulfonamide

Procedure

The title compound was prepared from 4-pentyl-1,3-thiazol-2-ylamine (METHOD I) and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (28.6 mg) with purity >90%. MS (pos) m/z 393.1, 395.1.

Sources & evidence

ORD record
ord-8e5d113ebfb748f18b10967fb0183477
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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