3-Chloro-2-methylbenzenesulfonyl chloride → HCID 11348511, compound

HRID 1245646Notes

Reaction equation

HRID 1245646 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[Cl:11][C:12]1[C:13]([CH3:22])=[C:14]([S:18](Cl)(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:18]([C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([Cl:11])[C:13]=2[CH3:22])(=[O:19])=[O:20])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 7208825-Acetyl-2-amino-4-methylthiazole

Product 1

HCID 11348511HCID 11348511, compound

Procedure

The title compound was prepared from 5-acetyl-2-amino-4-methylthiazole and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (10.8 mg) with purity >90%. LCMS (pos) m/z 345.0.

Sources & evidence

ORD record
ord-8e3ebe9e763e4fc6bd3cf95f26087ffe
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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