5-Acetyl-2-amino-4-methylthiazole → HCID 11351341, compound

HRID 1245647Notes

Reaction equation

HRID 1245647 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[Cl:11][C:12]1[C:13]([C:29]#[N:30])=[C:14]([CH:26]=[CH:27][CH:28]=1)[O:15][C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:22]([C:19]2[CH:18]=[CH:17][C:16]([O:15][C:14]3[CH:26]=[CH:27][CH:28]=[C:12]([Cl:11])[C:13]=3[C:29]#[N:30])=[CH:21][CH:20]=2)(=[O:23])=[O:24])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7208825-Acetyl-2-amino-4-methylthiazoleHCID 27769174-(3-Chloro-2-cyanophenoxy)benzenesulfonyl chloride

Product 1

HCID 11351341HCID 11351341, compound

Procedure

The tide compound was prepared from 5-acetyl-2-amino-4-methylthiazole and 4-(3-chloro-2-cyanophenoxy)benzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (9.9 mg) with purity >90%. LCMS (pos) m/z 448.0; LCMS (neg) m/z 446.0.

Sources & evidence

ORD record
ord-d84012c2d6d448b28a594b3bb5d5a8e1
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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