2,4,6-Trichlorobenzenesulfonyl chloride → N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,4,6-trichlorobenzenesulfonamide

HRID 1245649Notes

Reaction equation

HRID 1245649 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[C:13]=1[S:20](Cl)(=[O:22])=[O:21]>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:20]([C:13]2[C:14]([Cl:19])=[CH:15][C:16]([Cl:18])=[CH:17][C:12]=2[Cl:11])(=[O:22])=[O:21])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 5213352,4,6-Trichlorobenzenesulfonyl chlorideHCID 7208825-Acetyl-2-amino-4-methylthiazole

Product 1

HCID 11177040N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,4,6-trichlorobenzenesulfonamide

Procedure

The title compound was prepared from 5-acetyl-2-amino-4-methylthiazole and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (15.5 mg) with purity >90%. MS (pos) m/z 399.1, 401.1, 403.1.

Sources & evidence

ORD record
ord-f50053fc5b9a4a5087b6ab891b2c83a0
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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