5-Acetyl-2-amino-4-methylthiazole → HCID 11199814, compound

HRID 1245650Notes

Reaction equation

HRID 1245650 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([CH3:19])[C:13]=1[S:20](Cl)(=[O:22])=[O:21]>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:20]([C:13]2[C:14]([CH3:19])=[CH:15][C:16]([Cl:18])=[CH:17][C:12]=2[Cl:11])(=[O:22])=[O:21])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7208825-Acetyl-2-amino-4-methylthiazoleHCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chloride

Product 1

HCID 11199814HCID 11199814, compound

Procedure

The title compound was prepared from 5-acetyl-2-amino-4-methylthiazole and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (28.4 mg) with purity >90%. MS (pos) m/z 379.1, 381.1.

Sources & evidence

ORD record
ord-fd8f5b7a235b40cdaf36faca41e7a9c1
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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