2,4,5-Trichlorobenzenesulfonyl chloride → N-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-2,4,5-trichlorobenzenesulfonamide

HRID 1245651Notes

Reaction equation

HRID 1245651 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[C:15]([Cl:19])=[CH:14][C:13]=1[S:20](Cl)(=[O:22])=[O:21]>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:20]([C:13]2[CH:14]=[C:15]([Cl:19])[C:16]([Cl:18])=[CH:17][C:12]=2[Cl:11])(=[O:22])=[O:21])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 275752,4,5-Trichlorobenzenesulfonyl chlorideHCID 7208825-Acetyl-2-amino-4-methylthiazole

Product 1

HCID 11177041N-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-2,4,5-trichlorobenzenesulfonamide

Procedure

The title compound was prepared from 5-acetyl-2-amino-4-methylthiazole (42 mg) and 2,4,5-trichlorobenzenesulfonyl chloride (76 mg) as described in the synthetic METHOD B to give a white solid (23.7 mg) with purity >90%: MS (pos) m/z 399.2, 401.2; HRMS m/z 397.9103 (calc. of monoisotopic mass for C12H9Cl3N2O3S2 gives 397.9120).

Sources & evidence

ORD record
ord-8faa9a93be0b4ed69553cfa39c12c86d
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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