5-Acetyl-2-amino-4-methylthiazole → HCID 11269995, compound

HRID 1245652Notes

Reaction equation

HRID 1245652 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[Br:11][C:12]1[CH:13]=[C:14]([S:18](Cl)(=[O:20])=[O:19])[S:15][C:16]=1[Cl:17]>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:18]([C:14]2[S:15][C:16]([Cl:17])=[C:12]([Br:11])[CH:13]=2)(=[O:20])=[O:19])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7208825-Acetyl-2-amino-4-methylthiazoleHCID 27972204-Bromo-5-chlorothiophene-2-sulfonyl chloride

Product 1

HCID 11269995HCID 11269995, compound

Procedure

The title compound was prepared from 5-acety1-2-amino-4-methylthiazole (42 mg) and 4-bromo-5-chlorothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic METHOD B to give a white solid (11.7 mg) with purity >90%: MS (pos) m/z 415.3, 417.3.

Sources & evidence

ORD record
ord-a7e8861016734987835a3bfbb2e86126
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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