(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 10294534, compound

HRID 1245655Notes

Reaction equation

HRID 1245655 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=1.[C:13]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>>[C:13]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:16]([S:19]([NH:1][C:2]2[S:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=2)(=[O:21])=[O:20])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 343747Ethyl 2-amino-4-methylthiazole-5-carboxylate

Product 1

HCID 10294534HCID 10294534, compound

Procedure

This compound was prepared from ethyl 2-amino-4-methylthiazole-5-carboxylate and 4-biphenylsulfonyl chloride as described for EXAMPLE 30 with tile exception that it was not recrystallized. Yield 96 mg, 24%: 1H NMR (DMSO) δ 7.8-7.95 (m, 4H), 7.65-7.75 (m, 2H), 7.35-7.55 (m, 3H), 4.23 (q, 2H); 2.39 (s, 3H), 1.26 (t, 3H); MS-ES (neg) m/z 401.2.

Workup

  1. customwas not recrystallized

Sources & evidence

ORD record
ord-cd2f42b98fb44745a51bb39e124a96c0
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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