Ethyl 2-amino-4-methylthiazole-5-carboxylate → HCID 10177078, compound

HRID 1245656Notes

Reaction equation

HRID 1245656 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=1.[CH2:13]([C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1)[CH2:14][CH3:15]>>[CH3:7][C:5]1[N:6]=[C:2]([NH:1][S:22]([C:19]2[CH:20]=[CH:21][C:16]([CH2:13][CH2:14][CH3:15])=[CH:17][CH:18]=2)(=[O:24])=[O:23])[S:3][C:4]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 343747Ethyl 2-amino-4-methylthiazole-5-carboxylateHCID 27372224-N-Propylbenzenesulphonyl chloride

Product 1

HCID 10177078HCID 10177078, compound

Procedure

This compound was prepared from ethyl 2-amino-4-methylthiazole-5-carboxylate and 4-n-propylbenzenesulfonyl chloride as described for EXAMPLE 30 with the exception that it was not recrystallized. Yield 315 mg, 85%: 1H NMR (DMSO) δ 7.70 (d, 2H), 7.37 (d, 2H), 4.21 (q, 2H), 2.60 (t, 2H) 2.38 (s, 3H), 1.58 (t, 2H), 1.25 (t, 3H), 0.87 (t, 3H); MS-ES (neg) m/z 367.2.

Workup

  1. customwas not recrystallized

Sources & evidence

ORD record
ord-bdfc24712e5744c2b42295c3920d8510
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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