Ethyl 2-amino-4-methylthiazole-5-carboxylate → HCID 10202936, compound

HRID 1245658Notes

Reaction equation

HRID 1245658 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[CH3:7][C:5]1[N:6]=[C:2]([NH:1][S:22]([C:15]2[C:16]([Cl:21])=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=2[Cl:13])(=[O:24])=[O:23])[S:3][C:4]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 343747Ethyl 2-amino-4-methylthiazole-5-carboxylateHCID 5213352,4,6-Trichlorobenzenesulfonyl chloride

Product 1

HCID 10202936HCID 10202936, compound

Procedure

This compound was prepared from ethyl 2-amino-4-methylthiazole-5-carboxylate and 2,4,6-trichlorobenzenesulfonyl chloride as described for EXAMPLE 30 with the exception that it was purified by recrystaliation only. Yield 249 mg, 58%: 1HNMR (DMSO) δ 7.84 (s, 2H), 4.23 (q, 2H), 2.42 (s, 3H), 1.25 (t, 3H); MS-ES (neg) m/z 429.1.

Workup

  1. customwas purified by recrystaliation only

Sources & evidence

ORD record
ord-4dab2766f15b45c9a32e6cd672b66e5b
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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