2,5-Dibromopyridine → 1-[4-(5-Bromopyridin-2-yl)piperazin-1-yl]ethan-1-one

HRID 1245795Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[C:9]([N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)(=[O:11])[CH3:10]>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([N:15]2[CH2:16][CH2:17][N:12]([C:9](=[O:11])[CH3:10])[CH2:13][CH2:14]2)=[N:3][CH:4]=1

Participants

Reactant 2

HCID 693532,5-Dibromopyridine

HCID 837951-Acetylpiperazine

Product 1

HCID 219144681-[4-(5-Bromopyridin-2-yl)piperazin-1-yl]ethan-1-one

Procedure

Prepared from 2,5-dibromopyridine and 1-acetylpiperazine by the method of Example 13 (b).

Sources & evidence

ORD record: ord-748a264df55f411e90693e464ad70058
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07125896B2

Reaction notes

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