3-Furanol, tetrahydro- → 5-Bromo-2-[(oxolan-3-yl)oxy]pyridine

HRID 1245806Notes

Reaction equation

HRID 1245806 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[OH:9][CH:10]1[CH2:14][CH2:13][O:12][CH2:11]1>>[O:12]1[CH2:13][CH2:14][CH:10]([O:9][C:2]2[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 693532,5-Dibromopyridine

Product 1

HCID 219142665-Bromo-2-[(oxolan-3-yl)oxy]pyridine

Procedure

Prepared from 2,5-dibromopyridine and 3-hydroxytetrahydrofuran by the method of Example 10 (b). 1H NMR (DMSO-D6) 2.0 (m, 1H), 2.2 (m, 1H), 3.8 (m, 4H), 5.4 (m, 1H), 6.8 (d, 1H), 7.8 (m, 1H), 8.2 (m, 1H).

Sources & evidence

ORD record
ord-7d17d9847cfb4b1eac1edc12486124c7
Source dataset
uspto-grants-2006_10
Patent number
US07125896B2

Reaction notes

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