Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | 2-Bromobenzenethiol | HCID 80598 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21914394 | HCID 21914394 | — |
Reaction Steps
Potassium carbonate (10.95 g) and 2-chloroethylmorpholine hydrochloride (5.9 g) were mixed with dimethylformamide (50 ml) and 2-bromothiophenol was added before the mixture was heated to 100° C. for 3 days. The mixture was allowed to cool before water (500 ml) was added. The product was extracted into diethyl ether (×3). The combined extracts were dried over sodium sulphate and filtered before evaporation. The product was purified by column chromatography eluting with ethyl acetate/hexane mixtures to give a red/brown oil (6.024 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07125896B2 |
|---|
| Source dataset | uspto-grants-2006_10 |
|---|
| ORD ID | ord-a5528d95520141d38fef408ec2153174 |
|---|
| Source note | uspto-grants-2006_10 |
|---|
