Toluene → HCID 21914386, compound

Participants

Reaction Conditions

Reaction Steps

4-Bromo-3-(2-{piperidin-1-yl}ethoxy)aniline (2.99 g), 1,4-dibromobutane (1.2 ml), diisopropylethylamine (4.18 ml) and toluene (15 ml) were stirred and heated at 110° C. for 18 h. When cool, water (20 ml) was added, and the mixture was extracted with ethyl acetate (2×30 ml). The combined organic phase was washed with water, brine, dried (MgSO4) and evaporated to give the product as an orange-brown oil (2.25 g).

Provenance & Evidence