2-Bromophenol → HCID 21914346, compound

HRID 1245866Notes

Reaction equation

HRID 1245866 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].CS(O[CH:14]1[CH2:18][CH2:17][N:16]([CH2:19][CH:20]2[CH2:22][CH2:21]2)[CH2:15]1)(=O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH:14]1[CH2:18][CH2:17][N:16]([CH2:19][CH:20]2[CH2:22][CH2:21]2)[CH2:15]1

Participants

3

Reactant 2

HCID 72442-BromophenolHCID 21914415HCID 21914415, compound

Product 1

HCID 21914346HCID 21914346, compound

Procedure

The title compound was prepared from 2-bromophenol and 1-(cyclopropylmethyl)pyrrolidin-3-yl methanesulphonate in a similar manner to Example 134 (b) except that the compound was purified by cation exchange chromatography eluting with ammonia/methanol mixtures.

Workup

  1. customwas purified by cation exchange chromatography
  2. washeluting with ammonia/methanol mixtures

Sources & evidence

ORD record
ord-f774e695453442c294d445b1230588ec
Source dataset
uspto-grants-2006_10
Patent number
US07125896B2

Reaction notes

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