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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1245930Generated: October 26, 2026

trans-2-Phenylcyclopropyl isocyanate → N-{2-[2-(4-Amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethoxy]ethyl}-N'-[(1R*,2S*)-2-phenylcyclopropyl]urea

https://huagongshe.com/reaction/1245930

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttrans-2-Phenylcyclopropyl isocyanateHCID 255285—
Reactant1-[2-(2-aminoethoxy)ethyl]-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amineHCID 21913053—
ProductN-{2-[2-(4-Amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethoxy]ethyl}-N'-[(1R*,2S*)-2-phenylcyclopropyl]ureaHCID 23520158—

Reaction Steps

Using the method of Examples 54–68, trans-2-phenylcyclopropyl isocyanate was reacted with 1-[2-(2-aminoethoxy)ethyl]-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The product was purified using Method A. The observed accurate mass was 423.2508.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07125890B2
Source datasetuspto-grants-2006_10
ORD IDord-d8ab58b69dad4af691ad788bdea2b690
Source noteuspto-grants-2006_10